Bone regeneration by hydroxyapatite-gelatin nanocomposites

In the current research, preparation and characterization of a series new biocompatible injectable bone paste (IBP) nanocomposites, hydroxyapatite-gelatin (HA-Gel), hydroxyapatite-gelatin-alendronate (HA-Gel-Ald np) are reported. IBP HA-Gel np, were synthesized from mixing different ratios gelatin to aqueous solutions both Ca(NO3)2.4H2O (NH4)2HPO4, while target HA-Gel-Ald obtained by submitting solution alendronate (Ald) np nanocomposites. This composite crystallinity was analyzed FTIR XRD, their morphology characterized scanning electron microscopy (SEM) EDX measurements. XRD patterns, SEM, presented changes in crystal surface structure HA np. These physico-chemical measurements indicated success isolating with ratios. Furthermore, cytotoxicity nanocomposites on stem cells assessed using MTT assay. Although data show significant effect prepared (p = 0.00), interaction together had no 0.624). • New np). composites The